Drugs & Medications
What is Xarelto?
Xarelto (rivaroxaban) is an anticoagulant (blood thinner) that prevents the formation of blood clots.
Xarelto is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery.
Xarelto is also used in people with atrial fibrillation (a heart rhythm disorder) to lower the risk of stroke caused by a blood clot.
Xarelto may also be used for purposes not listed in this medication guide.
Important information about Xarelto
Xarelto can cause a very serious blood clot around your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, a history of spinal surgery or repeated spinal taps, or if you are using other medications to treat or prevent blood clots. Symptoms of this type of blood clot include numbness, tingling, muscle weakness, or loss of movement. Tell any doctor who treats you that you are using Xarelto. Many other drugs (including some over-the-counter medicines) can increase your risk of bleeding or life-threatening blood clots, and it is very important to tell your doctor about all medicines you have recently used.
Tell your caregivers at once if you have signs of bleeding such as black or bloody stools, coughing up blood, confusion, feeling like you might pass out, or any bleeding that will not stop.
Blood clots around the brain or spinal cord may occur if you use Xarelto with other drugs that can affect blood clotting, including aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) such as Advil or Motrin, and any other medications to treat or prevent blood clots.
Do not stop taking Xarelto without first talking to your doctor. Stopping suddenly can increase your risk of blood clot or stroke.
Before taking Xarelto
You should not use Xarelto if you are allergic to rivaroxaban, or if you have active or uncontrolled bleeding. Xarelto can cause a very serious blood clot around your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if you have:
FDA pregnancy category C. It is not known whether Xarelto will harm an unborn baby. However, this medicine could cause bleeding complications during childbirth. Tell your doctor if you are pregnant or plan to become pregnant while using Xarelto. It is not known whether rivaroxaban passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Xarelto.
How should I take Xarelto?
Take Xarelto exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Xarelto is usually taken once per day. Follow your doctor's instructions.
For hip or knee replacement surgery: You may take Xarelto with or without food.
For atrial fibrillation: Take Xarelto with your evening meal.
Tell any doctor who treats you that you are using Xarelto. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using Xarelto. If you need anesthesia for a medical procedure or surgery, you may need to stop using Xarelto for a short time.
Use Xarelto regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Do not stop taking this medication without first talking to your doctor. Stopping suddenly can increase your risk of blood clot or stroke.
Store Xarelto at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Take your next dose the following day and stay on your once-daily schedule. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose may cause excessive bleeding.
What should I avoid while taking Xarelto?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Xarelto side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Xarelto: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using Xarelto and call your doctor at once if you have a serious side effect such as:
What other drugs will affect Xarelto?
Tell your doctor about all other medicines you use, especially: